You are here : Home > INDUSTRIAL INNOVATION > DEMOS > A generic toolbox for microfluidics and point-of-care diagnostics

Articles & files | Focus | Article


Published on 19 April 2023

A generic toolkit for microfluidics and point-of-care diagnostics

   What is Flowpad-Flowstretch?

FlowPad features disposable, credit card format microfluidic cartridges with fluidic channels designed to perform a selection of tests outside of a traditional lab environment. The integrated protocol can be complex by including all sample preparation steps—concentration, lysis, purification—as well as bio-analysis and detection procedures—qPCR, RPA, LAMP and ELISA.

An instrument leverages a chip carrier, a functional implementation system based on the microfluidic cartridge design. This instrument integrates a valve, a pump and a mixing chamber and is embedded into a toolkit. This toolkit delivers the diagnosis. It integrates actuators, a Peltier heater, magnetic actuators and on-board reagent recovery, as well as an optical sensing system, and associated software programs.

Both instrument and microfluidic cartridges are customdesigned based on clinical or manufacturing requirements.


FlowPad finds applications in human medicine, agri-agro and environment industries:

  • Sample preparation at the sampling point —peptide, SiRNA isolation
  • Point-of-care testing and diagnostics —bacteria, viruses, biomarkers and proteins.
  • Companion diagnostic
  • Cell encapsulation—spheroids, cells, etc.
  • Assessment of Chemical, Biological, Radiological and Nuclear (CBRN) risks

   What's new?

CEA-Leti’s Flowpad-Flowstretch technology opens a new path to the future of testing:
  • Tests in less than 2 hours: from raw biological sample to results
  • Versatile, easy-to-use toolbox
  • Compatible with multiple complex protocols—biological, chemical, etc.—and materials—silicon, glass, COC, polymers, etc.
  • Reduces development and prototyping time
  • Easily scalable for high-volume production at low-cost. CEA-Leti has perfected cartridge design and small-scale production.
  • Full protocol integration

Flowpad-Flowstretch's Microfluidic cartridge:
  • are user-friendly features plug-and-play fluidic connections with easy and efficient flow control
  • operates with valves and a pump integrated into the cartridge
  • are compatible with injection molding

  What's next?

CEA-Leti is currently working in scaling to high-volume manufacturing both the cartridge and the instrument with industrial partners. 

New application: multiplex measurement card.


  •  5 fluidic connection patents filed


  • Quantitative biological assays with on-chip calibration using
    versatile architecture and collapsible chambers. C. Parent, F. Boizot,
    M. Cubizolles, N. Verplanck, J.-L. Achard, Y. Fouillet
  • Microfluidic device integrating a network of hyper-elastic valves for automated glucose stimulation and insulin secretion collection from a single pancreatic islet. C.Quintard, E.Tubbs, J-L.Achard, F.Navarro, X.Gidrol, Y.Fouillet
  • PepS: An Innovative Microfluidic Device for Bedside Whole Blood Processing before Plasma Proteomics Analyses. B.Gilquin, M.Cubizolles, R.Den Dulk, F.Revol-Cavalier, M.Alessio, C-E. Goujon, C.Echampard, G.Arrizabalaga, A.Adrait, M.Louwagie, P.Laurent, F.Navarro, Y.Couté, M-L.Cosnier, V.Brun
  •       FLYER