You are here : Home > INDUSTRIAL INNOVATION > DEMOS > Cytonote a CMOS sensor

Articles & files | Focus | Article


Cytonote - Iprasense

Cytonote - Iprasense

Compatible with any flask, this mini microscope can be positioned directly in the incubator to record images, videos and characterize the cell culture. It measures cell division rate, viability, migration and counting over long periods. A single glance at the monitor allows you to follow up to 20,000 cells by means of a 29.4 mm² CMOS sensor. Additionally, this low-cost technology is attractive because it is ultra-compact and robust. 

Published on 25 February 2017

Over 20,000 Cells at a Single Glance!

What is Cytonote? 
Compatible with any flask, this mini microscope can be positioned directly in the incubator to record images, videos and characterize the cell culture. It measures cell division rate, viability, migration and counting over long periods. A single glance at the monitor allows you to follow up to 20,000 cells by means of a 29.4 mm² CMOS sensor. Additionally, this low-cost technology is attractive because it is ultra-compact and robust. 


Applications: 

  • Bio-process monitoring: cell culture
  • Monitoring in incubators
  • Bacteria, virus and nanoparticle detection 
  • Pharmaceutical and toxicity studies
  • Fundamental biology
  • Screening R&D


What’s new? 
Developed in partnership with Iprasense, Cytonote offers a 29.4 mm² wide field of view displaying several thousand cells per image. Each mini reader features a LED and a CMOS sensor that tracks and records, in video format, the activity and growth of cell cultures without marking. No adjustment or configuration is required. The algorithms, designed by Leti researchers, take care of everything.

Leti has developed lensless imaging technology that increases field of view tenfold compared with the microscope. Holographic reconstruction is implemented to generate its screen usable images. The light emitted by a LED and diffracted by the cells plots a hologram pattern, which is recorded by the CMOS sensor. The researchers developed holographic algorithms to reconstruct the images obtained from these diffraction patterns. Energy-saving and ergonomic, its 132 cm² format is suited to every work surface. Cytonote is very easy-friendly, it works with any culture medium and delivers a clear, high-contrast image.

Patents: 
More than 10 patents