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Leti's Biosourced Materials


 



Published on 19 April 2019


 Drug Delivery Biosourced Materials

   What are Biosourced Materials?

Specializing in nanobiotechnologies, Leti develops biomaterials for drug delivery systems, such as aerogels,
patches for bandage and coating to speed up the wound healing process. Biosourced materials are processed from
natural biopolymers such as polysaccharides or polypeptides.
The chemical nature of such surfaces involves specific characterization, advanced material processing and drug
loading techniques. Leti researchers offer:

  • double encapsulation technology: encapsulation of lipophilic / hydrophobic drugs into lipid nanoparticles
    or cyclodextrins, which are then loaded into the material matrix
  • A controlled solution: material morphology and porosity are controlled during to the entire process
  • Various end-products: films, bulk materials hydrogels, microbeads and fibers
  • Further functionalities: conductivity and stretchability leveraging synthetic polymers (PEDOT, PANI, PEG, etc.)


  Applications :

By developing new Biosourced materials, Leti addresses new challenges in biotechnology and nanomedicine:

  • Trans-dermal or trans-mucosal drug delivery systems: drug-delivering patches, dressings

  • Support and coating for medical devices:
      - Support materials for biosensors
      - Coating for prostheses, medical devices

  • Injectable hydrogels and tissue reconstruction:
        - Injectable matrices for post-surgical tissue reconstruction
       - Resorbable localized drug delivery systems

  • 3D cell culture: Organs-on-chips, Drug and siRNA screening


   What’s new?

  • Materials with various mechanical properties (young modulus from one to hundreds of kPa) to match the elasticity of targeted tissues
  • Materials processed in different final forms, such as hydrogels, films, sponges or fibers, to match the targeted medical application
  • Material processing with various techniques to fit the active ingredients properties (spin coating, dip coating, molding & cross-linking, supercritical fluid deposition, electro-spinning, freeze-drying…)
  • Complete set of characterization processes available at Leti (structural, thermal, surface, rheological, mechanical, biological, optical spectroscopic…)

 What’s Next?

Leti is continuously working on improving its biosourced solutions.
Its team is currently developing:

  • Resorbable polymers with controlled kinetics of biodegradation (from days to years)
  • Multi-functional materials (stretchable, conductive)
  • Stimuli-triggered delivery

 

KEY POINTS:

4 patents

  •      FLYER

    flyer
       

Collagen sponge and chitosan film

Sponge hydrogel and film


Crosslinked hyaluronic acid aerogels


      © Leti – Credits photos : CEA/Leti – 2018/08